Muscle growth. Creatine may also play a role in increasing muscle mass or improving muscular growth. Increased creatine in muscle tissues increases something called osmotic pressure, which is.. Does creatine supplementation lead to dehydration and muscle cramping? 6. Is creatine supplementation harmful for children and adolescents? 7. Does creatine supplementation increase body fat?. (based on the upper limit of intramuscular creatine storage) may help explain some research showing diminished responsiveness and/or performance.

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Creatine may also help you reduce muscle breakdown and retain muscle during exercise. This may result in a greater amount of muscle in the long-term ( 11 ). Another long-term benefit of creatine.. It is not necessary to load creatine, but it can help you see results faster. To get the full benefit of creatine you must saturate your muscle cells with it. Using a small dose (5 grams), saturation will take up to 30 days, depending on the individual's lean body mass. However, by using a loading dosage of 15-25 grams per day for five days you.